Benzethonium Chloride: A Novel Anticancer Agent Identified by Using a Cell-Based Small-Molecule Screen
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Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen.
PURPOSE This study aims to identify a novel therapeutic agent for head and neck cancer and to evaluate its antitumor efficacy. EXPERIMENTAL DESIGN A cell-based and phenotype-driven high-throughput screening of approximately 2,400 biologically active or clinically used compounds was done using a tetrazolium-based assay on FaDu (hypopharyngeal squamous cancer) and NIH 3T3 (untransformed mouse e...
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Am. Nat. 151, 97 (1998); I. Hanski, Nature 396, 41 (1998); J. Swinton, J. Harwood, B. T. Grenfell, C. A. Gilligan, J. Anim. Ecol. 67, 56 (1998). 6. B. T. Grenfell and J. Harwood, Trends Ecol. Evol. 12, 395 (1997). 7. O. N. Bjørnstad, N. C. Stenseth, T. Saitoh, Ecology 80, 622 (1999). 8. M. P. Hassell, J. H. Lawton, R. M. May, J. Anim. Ecol. 46, 249 (1976); G. Sugihara and R. M. May, Nature 344,...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-0536